In AD: amyloid beta precursor protein (APP) is located on __. NeuroPathology In AD: amyloid beta precursor protein (APP) is located on __. Answer: chromosome 21 ( people with trisomy 21 (Down Syndrome) who thus have an extra gene copy almost universally exhibit AD by 40 years of age.) Learn More : Share this Share on FacebookTweet on TwitterPlus on Google+